Fowler Lab Recent Publications

Laboratory for Cellular Architecture

Publications

Recent Publications
1) Nowak, R.B., R.S. Fischer, R.K. Zoltoski, J.R. Kuszak and V.M. Fowler. Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens, submitted.

2) Castillo, A., K.P. Littlefield, R. Nowak, V.M. Fowler and R.S. Littlefield. (2009) A nebulin ruler does not dictate thin filament lengths. Biophys. J. 96:1856-1865.

3) McKeown, C.R., Nowak, R.B., Moyer, J., Sussman, M.A., and Fowler, V.M. Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ. Res. 103:1241-38, 2008.

4) Ilkovski, B., Mokbel, N., Lewis, R.A., Walker, K., Nowak, K., Domazetovska, A., Laing, N.G., Fowler, V.M., North, K.N., Cooper, S.T. (2008) Disease severity and thin filament regulation in M9R TPM3 nemaline myopathy. J. Neuropath. Exp. Neurol. 67:867-877.

5) Littlefield, R.S. and Fowler, V.M. Thin filament length regulation in striated muscle sarcomeres: Pointed-end dynamics go beyond a nebulin ruler. Sem. Cell Dev. Biol. 19:511-19, 2008.

6) Weber, K.L., Fischer, R.S. and Fowler, V.M. Tmod3 regulates polarized epithelial cell morphology. J. Cell Sci. 120:3625-32, 2007.

7) Fischer, R.S., E. G. Yarmola, K.L. Weber, K.D. Speicher, D.W. Speicher, M.R. Bubb, and V.M. Fowler. (2006) Tropomodulin3 binds to actin monomers, J. Biol. Chem. 281(47):36454-65.

8) Ehler, E., V.M. Fowler and J.-C. Perriard. (2003) Myofibrillogenesis in the developing chicken heart: role of actin isoforms and of the pointed end capping protein tropomodulin during thin filament assembly. Dev. Dyn. 229:745-755.

9) Fritz-Six, K.L., P.R. Cox, B. Xu, C.C. Gregorio, H.Y. Zoghbi and V.M. Fowler. (2003) Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J. Cell Biol. 163:1033-1044.

10) Fischer, R.S. and Fowler, V.M. Tropomodulins: Life at the slow end. Trends Cell Biol. 13:593-601, 2003.

11) Fowler, V.M., N.J. Greenfield and J. Moyer (2003) Tropomodulin contains two actin filament pointed end-capping domains. J. Biol. Chem. 278:40000-400009.

12) Mudry, R.E., C.N. Perry, M. Richards, V.M. Fowler and C.C. Gregorio. (2003) The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes. J. Cell Biol. 162:1057-1068.

13) Fischer, R.S., K.L. Fritz-Six and V.M. Fowler (2003) Actin pointed end capping by tropomodulin3 negatively regulates cell motility in endothelial cells. J. Cell Biol. 161:1-12.

14) Littlefield, R. and V.M. Fowler (2002) Measurement of thin filament lengths by distributed deconvolution analysis of fluorescence images. Biophys. J. 82:2548-2564.